Function
Ribosomal protein S5 (RPS5) is one of the 21 proteins which belong to the 30S of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome[1].
Relevance
RPS5 inhibitor exhibits potent inhibitory effect against liver fibrosis[2].
3D Structures of Ribosomal protein S5
Updated on 01-March-2022
Ribosomal protein S5 in part of small ribosomal subunit
1qd7 – TtRPS5+TtRPS4+TtRPS6+TtRPS7+TtRPS8+TtRPS15+TtRPS17+TtRPS20+16S RRNA fragment - Thermus thermophilus
1dv4 – TtRPS5+ TtRPS7+16S RRNA fragment
1pkp – GsRPS5 – Geobacillus stearothermophilus
2noq – yRPS5+yRPL1+18S RRNA+25S RRNA+CRPV IRES – yeast
References
- ↑ Ramakrishnan V, White SW. The structure of ribosomal protein S5 reveals sites of interaction with 16S rRNA. Nature. 1992 Aug 27;358(6389):768-71. PMID:1508272 doi:http://dx.doi.org/10.1038/358768a0
- ↑ Xu WH, Hu HG, Tian Y, Wang SZ, Li J, Li JZ, Deng X, Qian H, Qiu L, Hu ZL, Wu QY, Chai YF, Guo C, Xie WF, Zhang JP. Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis. Hepatology. 2014 Aug;60(2):648-60. doi: 10.1002/hep.27138. Epub 2014 May 9. PMID:24668691 doi:http://dx.doi.org/10.1002/hep.27138
