| Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |
Model Confidence:
Confident (90 > pLDDT > 70)
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.
To the right is an AlphaFold2 3D model of SARS CoV-2 Protein NSP6 (length = 290 amino acids, NCBI ID YP_009725302) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 3[1].
Function
Non-structural protein 6 (nsp6)
Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes[1][2][3].
Disease
Relevance
Structural highlights
Morph of the top 5 ranked
AlphaFold2 models of
SARS-CoV-2 Protein NSP6,
rainbow color coded N-C (blue to red)
[1].
See also
Coronavirus_Disease 2019 (COVID-19)
SARS-CoV-2_virus_proteins
COVID-19 AlphaFold2 Models
