| Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |
Model Confidence:
Confident (90 > pLDDT > 70)
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.
To the right is an AlphaFold2 3D model of SARS CoV-2 Protein ORF6 (length = 61 amino acids, NCBI ID QHD43420.1) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 3[1].
Function
Open Reading Frame 6 (ORF6)
Could be a determinant of virus virulence, since, when expressed in an otherwise attenuated JHM strain of murine coronavirus, it can dramatically increase the lethality of the latter. Seems to stimulate cellular DNA synthesis in vitro.[2][3]
Disease
Relevance
Structural highlights
Morph of the top 5 ranked
AlphaFold2 models of
SARS-CoV-2 Protein ORF6,
rainbow color coded N-C (blue to red)
[1].
See also
Coronavirus_Disease 2019 (COVID-19)
SARS-CoV-2_virus_proteins
COVID-19 AlphaFold2 Models
