Toll-like Receptor 3D structures

From Proteopedia

3D Structures of Toll-like Receptors

Updated on 27-December-2023 - For a general description of the protein see Toll-like Receptors

Toll-like receptor 1; Domains – Transmembrane+juxtamembrane 581-629; TIR 625-785; ligand-binding (LBD) 22-703; transmembrane 698-730

1fyv – hTLR1 TIR domain – human

6nih - hTLR1/VLRB.61

2z7x, 2z81, 2z82 – hTLR1/VLRB.61 + hTLR2/VLRB.61 + lipopeptide

Toll-like receptor 2

8ar0, 8ar1, 8ar2, 8ar3 – hTLR2 transmembrane+juxtamembrane domain – NMR

1fyw, 7nux, 7nux – hTLR2 TIR domain

7nt7 – hTLR1 TIR domain – NMR

1fyx, 1o77 - hTLR2 TIR domain (mutant)

2z80 – hTLR2/VLRB.61

3a79 – hTLR2/VLRB.61 + hTLR6/VLRB.61 + lipopeptide

6nig – hTLR2/VLRB.61 + diprovocim

3a7b - mTLR2/VLRB.61 – mouse

3a7c - mTLR2/VLRB.61 + PE-DTPA

5d3i – mTLR2 + SSL3

Toll-like receptor 3

1ziw, 2a0z – hTLR3 LBD

5gs0 – hTLR3 ectodomain + antibody

2mk9, 2mka – hTLR3 transmembrane domain - NMR

3ulv, 3ulu, 5gs0 – hTLR3 LBD + antibody

7c76 – hTLR3 + UNC93B1 – Cryo EM

7wm4, 7wv3, 7wv4, 7wv5, 7wvj – hTLR3 LBD + RNA – Cryo EM

7wve – hTLR3 LBD (mutant) + RNA – Cryo EM

7wvf – hTLR3 LBD + antibody + RNA – Cryo EM

7c77 – mTLR3 + UNC93B1 – Cryo EM

7da7, 7das – mTLR3 LBD + RNA – Cryo EM

3cig – mTLR3 LBD

3ciy - mTLR3 LBD + RNA

Toll-like receptor 4

2z62, 2z63, 2z66, 3ul9 – hTLR4/VLRB.61

3ul8, 3ul7 – hTLR4/VLRB.61 (mutant)

5nam, 5nao – hTLR4 transmembrane domain - NMR

3fxi, 4g8a - hTLR4 LBD + lymphocyte antigen 96

3ula - hTLR4/VLRB.61 + lymphocyte antigen 96

2z64, 2z65, 5ijc, 5ijd, 3vq1, 3vq2 – mTLR4 LBD + lymphocyte antigen 96

7mlm - mTLR4/VLRB.61 + lymphocyte antigen 96 + sulfatide

Toll-like receptor 5

3j0a – hTLR5

Toll-like receptor 5A

7b1b, 7b1c, 7b1d – TLR5A + Spz1C – yellow fever mosquito - Cryo EM

Toll-like receptor 5B

5gy2 – zfTLR5B N-terminal + flagellin - zebrafish

6bxa – zfTLR5B N-terminal + VLR2

6bxc – zfTLR5B N-terminal + VLR9

3v44, 6bxa, 6bxc – zfTLR5B/VLRB.61

3v47 – zfTLR5B/VLRB.61 + flagellin

Toll-like receptor 6

4om7 – hTLR6 TIR domain

Toll-like receptor 7

7cyn – hTLR7 + UNC93B1 – Cryo EM

5gmf – moTLR7 + guanosine + poly-U - monkey

5gmg – moTLR7 + loxoribine + poly-U

5gmh – moTLR7 + resiquimod + poly-U

5zsl, 5zsm, 5zsn – moTLR7 (mutant) + RNA

5zsg, 5zsh, 5zsi, 5zsj, 6lvz, 6lw1, 7ytp – moTLR7 (mutant) + inhibitor

6lvx, 6lvy, 6lw0 – moTLR7 (mutant) + antagonist

6if5 – moTLR7 (mutant) + cGMP

5zsf – moTLR7 (mutant) + drug

5zsa, 5zsb, 5zsd, 5zse – moTLR7 (mutant) + RNA + inhibitort

Toll-like receptor 8

3w3g, 5hdh – hTLR8

3w3j, 3w3k, 3w3l, 3w3m, 3w3n, 3wn4, 5awa, 5awc, 5awb, 5awd, 4r6a, 4qbz, 4qc0, 5az5, 6v9u, 6wml, 6zjz, 7crf, 7r52, 7r53, 7r54 – hTLR8 + agonist

6kya, 6ty5, 7rc9, 7ytx, 8pfi – hTLR8 + antagonist

4r07, 4r09 – hTLR8 + ORN06

4r08 – hTLR8 + RNA

4r0a – hTLR8 + uridine

5z14, 5z15, 5wyx, 5wyz – hTLR8 + inhibitor

Toll-like receptor 9

3wpb – hoTLR9 - horse

3wpc, 3wpd, 3wpe, 5y3j, 5y3k, 5y3l, 5y3m – hoTLR9 + DNA

3wpf – mTLR9

3wpg, 3wph, 3wpi – mTLR9 + DNA

5zln – mTLR9 (mutant) + DNA

4qdh – mTLR9/VLRB.61

Toll-like receptor 10

2j67 – hTLR10 TIR domain

Toll-like receptor 13

4z0c – mTLR13 + RNA

Toll-like receptor 15

7ylf, 7ylg – TLR10 TIR domain - chicken