Tositumomab
From Proteopedia
proteopedia linkproteopedia link Pharmacokinetics
Anti-CD20 Monoclonal Antibody Pharmacokinetics [1]
|
Parameter
| Tositumomab
| Ofatumumab
| Rituximab
| Ibritumomab
|
Tmax (hr)
| Tositumomab
| 7.6
| Rituximab
| Ibritumomab
|
Cmax (ng/ml)
| Tositumomab
| 167000
| 205800
| 67000
|
Bioavailability (%)
| Tositumomab
| Ofatumumab
| Rituximab
| Ibritumomab
|
T1/2 (hr)
| 64.8
| 68
| 206
| 108
|
AUC (ng/ml/hr)
| Tositumomab
| 32939000
| Rituximab
| 17000
|
Clearance (L/h)
| .078
| .017
| .009
| Ibritumomab
|
IC50 (nM)
| Tositumomab
| Ofatumumab
| Rituximab
| Ibritumomab
|
Dosage
| Tositumomab
| 500 mg (4th Infusion)
| 325 mg/m2 (4th Infusion)
| Ibritumomab
|
Metabolism
| Tositumomab
| Ofatumumab
| Rituximab
| Ibritumomab
|