Transcription initiation factors 3D structures

From Proteopedia

3D structures of transcription initiation factors

Updated on 31-December-2023 - For a general description of the protein see Transcription initiation factor

TFIIA

5m4s – hTFIIA – human

1nvp – hTFIIA + TBP + DNA

6mzm – hTFIIA+TFIID + TBP + DNA – Cryo EM

1nh2, 1rm1, 1ytf – yTFIIA + TBP + DNA – yeast

7oh9, 7oha – yTFIIA in nucleosome complex - CryoEM

5fur – yTFIIA + yTFIIF + TBP + DNA - CryoEM

TFIIB

1tfb – hTFIIB – NMR

1dl6 - hTFIIB N terminal – NMR

5wh1 - hTFIIB C terminal

1rly - hTFIIB Zn ribbon domain + Zn – NMR

1ro4 - hTFIIB Zn ribbon domain – NMR

1c9b, 1vol  – hTFIIB + TBP + DNA

1ais, 1d3u - TFIIB C terminal + TBP + DNA – Pyrococcus woesei

1pft – PfTFIIB N terminal – Pyrococcus furiosus – NMR

5o9i, 5o9j - TFIIB – Methanocaldococcus jannaschii

TFIIA+TFIIB

6o9l – hTFIIA+TFIIB in RNA polymerase II – Cryo EM

7zwc – hTFIIA+TFIIB + SNAPc:TBP – Cryo EM

TFIIIB

5n9g – hTFIIIB + TBP + DNA

6f40, 6f41, 6f42, 6f44, 6cnb, 6cnc, 6cnd, 6cnf, 6eu0 – yTFIIIB + RNA polymerase III – Cryo EM

7q5b – yTFIIIB in TY3 retrotransposon complex – Cryo EM

TFIID

1bh8 – hTFIID

1eqf, 7k3o – hTFIID subunit 1

6fic, 7jjg, 7jjh, 7jsp, 7jtc, 7k03, 7k0d, 7k0u, 7k1p, 7k27, 7k42, 7k6f, 7l6x, 7lb0, 7lb1, 7lb2, 7lb3, 7n42, 7p4s, 7t2i, 7t36 – hTFIID subunit 1 + inhibitor

3uv5 – hTFIID subunit 1 bromodomain 1-2

3uv4 – hTFIID subunit 1 bromodomain 2 1501-1635

5mg2, 6bqd, 6p38, 6p39, 6p3a – hTFIID subunit 1 bromodomain 2 + inhibitor

3aad – hTFIID subunit 1 bromodomain 1-2 + histone chaperone ASF1A

4yym, 4yyn – hTFIID subunit 1 bromodomain 2 + histone peptide

5i1q, 5i29 – hTFIID subunit 1 bromodomain 2 + pyrrolopyridone

5c13, 5wxg, 5wxh, 5xmy – hTFIID subunit 3 PHD finger 853-915 + histone peptide

5eg2 - hTFIID subunit 10 + SETD7 + SAH

4wv4 - hTFIID subunits 8+10

4grw - hTFIID subunits 1+7

6f3t - hTFIID subunits 5+6+9

6mzl, 7eg9, 7egb, 7egc, 7ege, 7ena, 7enc - hTFIID subunits 1-13 + TBP – Cryo EM

6mzd, 7egf - hTFIID subunits 1,3-6,9-13 + TBP – Cryo EM

6mzc, 7egg - hTFIID subunits 2,4-6,8-12 – Cryo EM

7egh - hTFIID subunits 1,2,6-8 + DNA – Cryo EM

7ktr, 7kts, 8h7g - hTFIID in SAGA coactivator complex – Cryo EM

1bh9 – hTFIID + PCMBS

6df4, 6df7 – TFIID subunit 1 bromodomain 2 + inhibitor - rabbit

1tba – TFIID – Drosophila melanogaster - NMR

1qn3, 1qn4, 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne – AtTFIID + DNA

7ac1 - AtTFIID subunit 4 RST domain - NMR

4oy2 - yTFIID subunits 1+7

6mip - yTFIID subunit 14

6lqz - yTFIID subunit 14 + STH1EBMC - NMR

5d7e, 5iok, 6min, 6mio, 6miq, 7f4a – yTFIID subunit 14 YEATS domain 1-137 + histone peptide

7uhe – yTFIID subunit 14 ET domain 168-243 + C-terminal domain 1392-1403

6t9j - yTFIID subunit 12 + Spt20 + transcription-associated protein – Cryo EM

6t9i, 6t9k - yTFIID in SAGA complex – Cryo EM

6hqa, 6tb4, 6tbm - TFIID in SAGA complex – Komagataella phaffii – Cryo EM

TFIID+TFIIA

7egd, 7egi, 7egj – hTFIID+TFIIA + TBP + DNA – Cryo EM

TFIIE

7nvw, 7nvx – hTFIIE + TFIIH + Mat1 + DNA – Cryo EM

5gpy - hTFIIE subunit 1 1-217 + subunit 2 141-217

1vd4 - hTFIIE Zn finger domain 113-174 – NMR

2rnq – hTFIIE C terminal 378-439 - NMR

2rnr – hTFIIE C terminal + TFIIH PH domain- NMR

6pin, 6xjf – PfTFIIE-a

TFIIF

1f3u – hTFIIF

1nha – hTFIIF C terminal - NMR

1i27 – hTFIIF C terminal (mutant)

1j2x – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide

1onv – hTFIIF C terminal + serine phosphatase peptide - NMR

2k7l – hTFIIF C terminal + FCP1 peptide - NMR

7mei, 7mk9 – yTFIIH in trailing EC complex – Cryo EM

TFIIH

5ivw, 6o9m, 7o4k, 7o4l – hTFIIH in preinitiation complex – Cryo EM

TF in RNA polymerase II

5iy6, 5iy7, 5iy8, 5iy9, 5iya, 5iyb, 5iyc, 5iyd – hTFIIA + hTFIIB + hTFIIE + hTFIIF + hTFIIH + DNA – Cryo EM

7edx, 7eg7, 7eg8, 7eg9, 7ega, 7nvv, 7nvy, 7nvz, 7nw0 – hTFII in RNA polymerase – Cryo EM

8wb0 – hTFIIF + in RNA polymerase II transcription pre-initiation complex - CryoEM

8iue, 8iuh – hTFIID + in RNA polymerase III pre-initiation complex - CryoEM

7nvr, 7nvs, 7nvt, 7nvu – hTFIIA + TFIIB + TFIIE + TFIIF + in mediator with RNA polymerase II transcription pre-initiation complex - CryoEM

5fyw – yTFIIA + yTFIIE + yTFIIF + DNA

5fz5, 6gyl, 6gym – yTFIIA + yTFIIE + yTFIIF + DNA – Cryo EM

6gyk – yTFIIA + yTFIIB + yTFIIF + DNA – Cryo EM

5sva – yTFIIA + yTFIIB + yTFIIE + yTFIIF + DNA – Cryo EM

4v1n, 4v1o – yTFIIB + yTFIIF – Cryo EM

7ml0, 7ml2, 7ml4 - yTFIIB + TFIIE + TFIIF + in RNA polymerase II pre-initiation complex - CryoEM

3k1f, 3k7a, 4bbr, 4bbs – yTFIIB in RNA polymerase complex

7o72 – yTFIIB in RNA polymerase II transcription pre-initiation complex - CryoEM

7o73 – yTFIIA + TFIIE + TFIIF + in RNA polymerase II transcription pre-initiation complex - CryoEM

7o4i, 7o4j, 7o75 – yTFIIA + TFIIB + TFIIE + TFIIF + in RNA polymerase II transcription pre-initiation complex - CryoEM

7zs9, 7zsa, 7zsb, 8bz1 – yTFIIA + TFIIB + TFIID + TFIIE + TFIIF + nucleosome in RNA polymerase II transcription pre-initiation complex - CryoEM

5fmf, 5oqj, 5oqm – yTFIIA + yTFIIB + yTFIIE + yTFIIF + yTFIIH + DNA – Cryo EM

6kf4, 6kf9 – TFIIF – Thermococcus kodakarensis - Cryo EM

TF RRN or RNA polymerase I-specific transcription initiation factor RRN

7oba – hTF RRN3 in RNA polymerase I – Cryo EM

3tj1 – yTF RRN3

5g5l – yTF RRN3 in RNA polymerase I

6rqt, 6rrd – yTF RRN3 in RNA polymerase I – Cryo EM

6ruo – yTF RRN3+RRN6+RRN11 in RNA polymerase I – Cryo EM

5o7x – yTF RRN6+RRN7+RRN11

5oa1, 5w5y, 5w64, 5w65, 5w66 – yTF RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM

5n5y, 5n5z, 5n60, 5n61, 6rqh, 6rql, 6rui, 6rwe – yTF RRN3+RRN6+RRN7+RRN11 in RNA polymerase I – Cryo EM

7z0o – yTF RRN5+RRN9+RRN10 in RNA polymerase I – Cryo EM

Arabidopsis thaliana