User:Mary Ball/Leptin

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PDB ID 1ax8

Human obesity protein leptin-E100 1ax8
Gene: OBESE GENE (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

HUMAN OBESITY PROTEIN, LEPTIN

Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest. Most human obesity does not appear to result from a mutant form of leptin: rather, serum leptin concentrations are increased and there is an apparent inability to transport it to the central nervous system (CNS). Injection of leptin into the CNS of overfed rodents resistant to peripheral administration was found to induce biological activity. Consequently, for the leptin to act as a weight-lowering hormone in human obesity, it appears that appropriate concentrations must be present in the CNS. This places a premium on understanding the structure of the hormone in order to design more potent and selective agonists.

Quiz

1. Most human obesity is the result of mutant forms of leptin.

True
False
Most obese humans actually have increased concentrations of normal leptin. So maybe cells in the brains of many obese people are just unresponsive to leptin.

2. Leptin is a type of:

Gene
Protein
RNA
Carbohydrate
The mouse gene named obese was found to code for a protein, which was named leptin.

3.

What gene symbol was assigned to the obese gene?

4. What is the biological function of leptin?

It is an enzyme.
It is a membrane receptor.
It is a hormone.
It is an intracellular hormone receptor.

5. Which of these structures represents Leptin?


Your score is 0 / 0


Additional Reading

  • "Gimmick-Free Weight-Loss Pill in the Works", January 2010 article from Science Daily News.


Publication Abstract from PubMed

Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest. Most human obesity does not appear to result from a mutant form of leptin: rather, serum leptin concentrations are increased and there is an apparent inability to transport it to the central nervous system (CNS). Injection of leptin into the CNS of overfed rodents resistant to peripheral administration was found to induce biological activity. Consequently, for the leptin to act as a weight-lowering hormone in human obesity, it appears that appropriate concentrations must be present in the CNS. This places a premium on understanding the structure of the hormone in order to design more potent and selective agonists. Here we report the crystal structure at 2.4A resolution of a human mutant OB protein (leptin-E100) that has comparable biological activity to wild type but which crystallizes more readily. The structure reveals a four-helix bundle similar to that of the long-chain helical cytokine family.

Crystal structure of the obese protein leptin-E100., Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW, Nature. 1997 May 8;387(6629):206-9. PMID:9144295

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1AX8 is a 1 chain structure of sequence from Homo sapiens.

3D structures of leptin

Updated on 19-August-2014

1ax8 - Leptin (mutant) - human


Reference

  • Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature. 1997 May 8;387(6629):206-9. PMID:9144295 doi:10.1038/387206a0

Proteopedia Page Contributors and Editors (what is this?)

Mary Ball, Jaime Prilusky, Michal Harel, Eran Hodis

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