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H. sapiens Lipoprotein Lipase in complex with GPIHBP1 and triglyceride metabolism

Lipoprotein lipase (green) bound to GPIHBP1 (cyan) (PDB 6OB0)

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References

  1. 1.0 1.1 1.2 Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M. GPIHBP1 and Plasma Triglyceride Metabolism. Trends Endocrinol Metab. 2016 Jul;27(7):455-469. doi: 10.1016/j.tem.2016.04.013. , Epub 2016 May 14. PMID:27185325 doi:http://dx.doi.org/10.1016/j.tem.2016.04.013
  2. 2.0 2.1 Voss CV, Davies BS, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG. Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7980-4. doi:, 10.1073/pnas.1100992108. Epub 2011 Apr 25. PMID:21518912 doi:http://dx.doi.org/10.1073/pnas.1100992108
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Arora R, Nimonkar AV, Baird D, Wang C, Chiu CH, Horton PA, Hanrahan S, Cubbon R, Weldon S, Tschantz WR, Mueller S, Brunner R, Lehr P, Meier P, Ottl J, Voznesensky A, Pandey P, Smith TM, Stojanovic A, Flyer A, Benson TE, Romanowski MJ, Trauger JW. Structure of lipoprotein lipase in complex with GPIHBP1. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10360-10365. doi:, 10.1073/pnas.1820171116. Epub 2019 May 9. PMID:31072929 doi:http://dx.doi.org/10.1073/pnas.1820171116
  4. 4.0 4.1 Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metab. 2019 Jul 2;30(1):51-65. doi: 10.1016/j.cmet.2019.05.023. PMID:31269429 doi:http://dx.doi.org/10.1016/j.cmet.2019.05.023
  5. Olivecrona G. Role of lipoprotein lipase in lipid metabolism. Curr Opin Lipidol. 2016 Jun;27(3):233-41. doi: 10.1097/MOL.0000000000000297. PMID:27031275 doi:http://dx.doi.org/10.1097/MOL.0000000000000297
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 1817984116. doi:, 10.1073/pnas.1817984116. PMID:30559189 doi:http://dx.doi.org/10.1073/pnas.1817984116
  7. Hedstrom L. Serine Protease Mechanism and Specificity. Chemical Reviews 2002 102 (12), 4501-4524 https://doi.org/10.1021/cr000033x



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