Variable lymphocyte receptor

From Proteopedia

spinqualitylabelsall models Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) (3g3a), resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Variable lymphocyte receptors (VLRs) are leucine-rich repeat (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. [1] . Lamprey Variable Lymphocyte Receptor in complex with a protein antigen (3g3a) See Also Lamprey Variable Lymphocyte Receptor Leucine-rich Repeat Proteins Antibody Forkhead box protein 3D structures of variable lymphocyte receptor Variable lymphocyte receptor 3D structures

Articles in Proteopedia concerning Variable lymphocyte receptors include:

• Lamprey Variable Lymphocyte Receptor

Additional Literature

• Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
• Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
• Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
• Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
• Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
• Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
• Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834

References

1. ↑ Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200