Virion infectivity factor

From Proteopedia

spinqualitylabelsall models HIV-1 virion infectivity factor (deep sky blue) complex with human elongin-B (green) and elongin-C (pink) (PDB code 2ma9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions[1]. . For details see HIV and accessory proteins

3D Structures of virion infectivity factor

Updated on 19-March-2024

4n9f – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – HIV-1
8fvi, 8fvj – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – Cryo EM
2ma9, 3dcg – HIVVif + elongin-C + elongin-B
6nil – HIVVif + CBF-β + AF3 - Cryo EM
8cx0, 8cx1, 8cx2 – HIVVif + elongin-C + elongin-B + CBF-β + RNA – Cryo EM
8e40 – HIVVif + deoxycytidine deaminase + CBF-β + RNA – Cryo EM
6p59 – Vif + elongin-C + elongin-B + CBF-β – SIV-1
7upn – Vif + elongin-C + elongin-B + PPIase A – Visna-Maedi virus – Cryo EM

References

1. ↑ Rose KM, Marin M, Kozak SL, Kabat D. The viral infectivity factor (Vif) of HIV-1 unveiled. Trends Mol Med. 2004 Jun;10(6):291-7. PMID:15177194 doi:http://dx.doi.org/10.1016/j.molmed.2004.04.008