View source for 7ypc


==Notothenia coriiceps TRAF4==
<StructureSection load='7ypc' size='340' side='right'caption='[[7ypc]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ypc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YPC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ypc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ypc OCA], [https://pdbe.org/7ypc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ypc RCSB], [https://www.ebi.ac.uk/pdbsum/7ypc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ypc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A6I9N9S6_9TELE A0A6I9N9S6_9TELE] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Due to an increasing interest in immunity and signal transduction in teleost fish, important key signaling molecules associated with the immune response, including TRAF molecules, have been recently cloned and characterized. To better understand the role of TRAF4 in fish immune signaling and compare it with the human system, our study cloned the TRAF4 gene from the Antarctic yellowbelly rockcod Notothenia coriiceps (ncTRAF4) and purified the protein. Here, we report the first crystal structure of teleost fish TRAF4. Based on biochemical characterization, our findings elucidated the mechanisms through which signaling molecules gain cold adaptivity. Additionally, we identified a platelet receptor GPIbbeta homolog in N. coriiceps (ncGPIbbeta) and found that the "RRFERLFKEARRTS" region of this homolog directly binds to ncTRAF4, indicating that ncTRAF4 also recognizes the "RLXA" motif for receptor interactions and further TARF4-mediated cellular signaling. Collectively, our findings provide novel insights into the mechanisms of TRAF4-mediated immune cell and platelet signaling in fish and the structural flexibility-mediated cold adaptiveness of signaling molecules.

Structure of fish TRAF4 and its implication in TRAF4-mediated immune cell and platelet signaling.,Kim CM, Jang H, Hong E, Lee JH, Park HH Fish Shellfish Immunol. 2023 Jan;132:108462. doi: 10.1016/j.fsi.2022.108462. Epub , 2022 Nov 29. PMID:36455779<ref>PMID:36455779</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7ypc" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Notothenia coriiceps]]
[[Category: Jang HS]]
[[Category: Kim CM]]
[[Category: Park HH]]