View source for 8g6d


==HSV-1 Nuclear Egress Complex (SUP; UL31-R229L)==
<StructureSection load='8g6d' size='340' side='right'caption='[[8g6d]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8g6d]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G6D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g6d OCA], [https://pdbe.org/8g6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g6d RCSB], [https://www.ebi.ac.uk/pdbsum/8g6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g6d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEC2_HHV11 NEC2_HHV11] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04024]<ref>PMID:12805460</ref> <ref>PMID:15140953</ref> <ref>PMID:15140956</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Draganova EB]]
[[Category: Gonzalez Del-Pino GL]]
[[Category: Heldwein EE]]