View source for 9j8d


==Human Glycine Transporter 1 in the Iclepertin-Bound State with an Inward-Facing Conformation==
<StructureSection load='9j8d' size='340' side='right'caption='[[9j8d]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9j8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J8D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EBX:[5-methylsulfonyl-2-[(2~{R})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-phenyl]-[(1~{R},5~{R})-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone'>A1EBX</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j8d OCA], [https://pdbe.org/9j8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j8d RCSB], [https://www.ebi.ac.uk/pdbsum/9j8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j8d ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC6A9_HUMAN SC6A9_HUMAN] Atypical glycine encephalopathy;Infantile glycine encephalopathy. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SC6A9_HUMAN SC6A9_HUMAN] Sodium- and chloride-dependent glycine transporter (PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses.[UniProtKB:P28571]<ref>PMID:8183239</ref>   Sodium- and chloride-dependent glycine transporter.<ref>PMID:8183239</ref>   Sodium- and chloride-dependent glycine transporter.<ref>PMID:8183239</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li N]]
[[Category: Li R]]
[[Category: Wei Y]]
[[Category: Zhao Y]]