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<StructureSection load='5llk' size='340' side='right' caption='Human α-dystroglycan complex with ethylelene glycol (PDB code [[5llk]])' scene=''> == Function == '''Dystroglycan''' (DG) is a central component of the dystrophin-glycoprotein complex which plays a critical role in a variety of muscular dystrophies<ref>PMID:9175728</ref>. α- and β-dystroglycan constitute a membrane-spanning complex that connects the extracellular matrix to the cytoskeleton<ref>PMID:16410545</ref>. DG is a cell-surface laminin receptor which is expressed in cells contacting basement membrane in developing and adult tissue<ref>PMID:9865703</ref>. == Disease == Muscle-eye-brain disease patients exhibit deficiency in α-DG<ref>PMID:11883957</ref>. There is a relationship between aberrant glycosylation of α-DG and congenital muscular dystrophies<ref>PMID:16550917</ref>. == Structural highlights == DG is encoded by a single gene and is cleaved into α- and β-DG posttranslationally. </StructureSection> == 3D Structures of α-dystroglycan == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} [[5llk]] – hDG α (mutant) – human <br /> [[1u2c]] – mDG α – mouse <br /> [[5n30]], [[4wiq]], [[5n4h]] – mDG α N-terminal (mutant) <br /> == References == <references/> [[Category:Topic Page]]

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