1dll
From Proteopedia
(New page: 200px<br /><applet load="1dll" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dll, resolution 1.8Å" /> '''THE HC FRAGEMENT OF T...) |
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| - | [[Image:1dll.gif|left|200px]]<br /><applet load="1dll" size=" | + | [[Image:1dll.gif|left|200px]]<br /><applet load="1dll" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dll, resolution 1.8Å" /> | caption="1dll, resolution 1.8Å" /> | ||
'''THE HC FRAGEMENT OF TETANUS TOXIN COMPLEXED WITH LACTOSE'''<br /> | '''THE HC FRAGEMENT OF TETANUS TOXIN COMPLEXED WITH LACTOSE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The entry of tetanus neurotoxin into neuronal cells proceeds through the | + | The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding. |
==About this Structure== | ==About this Structure== | ||
| - | 1DLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with LAT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http:// | + | 1DLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=LAT:'>LAT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Tentoxilysin]] | [[Category: Tentoxilysin]] | ||
[[Category: Black, I.]] | [[Category: Black, I.]] | ||
| - | [[Category: Charles, I | + | [[Category: Charles, I G.]] |
[[Category: Emsley, P.]] | [[Category: Emsley, P.]] | ||
| - | [[Category: Fairweather, N | + | [[Category: Fairweather, N F.]] |
[[Category: Fotinou, C.]] | [[Category: Fotinou, C.]] | ||
[[Category: Hewitt, E.]] | [[Category: Hewitt, E.]] | ||
| - | [[Category: Isaacs, N | + | [[Category: Isaacs, N W.]] |
[[Category: Watts, C.]] | [[Category: Watts, C.]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: jelly roll]] | [[Category: jelly roll]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:53 2008'' |
Revision as of 10:17, 21 February 2008
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THE HC FRAGEMENT OF TETANUS TOXIN COMPLEXED WITH LACTOSE
Overview
The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
About this Structure
1DLL is a Single protein structure of sequence from Clostridium tetani with and as ligands. Active as Tentoxilysin, with EC number 3.4.24.68 Full crystallographic information is available from OCA.
Reference
The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735
Page seeded by OCA on Thu Feb 21 12:17:53 2008
Categories: Clostridium tetani | Single protein | Tentoxilysin | Black, I. | Charles, I G. | Emsley, P. | Fairweather, N F. | Fotinou, C. | Hewitt, E. | Isaacs, N W. | Watts, C. | GOL | LAT | Beta trefoil | Jelly roll
