9hfe
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9hfe is ON HOLD Authors: Casale, G., Le Bihan, Y.-V., van Montfort, R.L.M., Guettler, S. Description: Crystal structure of human TRF1 TRFH domain i...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human TRF1 TRFH domain in complex with compound 10== | |
| - | + | <StructureSection load='9hfe' size='340' side='right'caption='[[9hfe]], [[Resolution|resolution]] 2.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9hfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HFE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PK4:2-fluoranyl-~{N},3-dimethyl-benzenesulfonamide'>PK4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hfe OCA], [https://pdbe.org/9hfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hfe RCSB], [https://www.ebi.ac.uk/pdbsum/9hfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hfe ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Guettler | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Casale G]] | ||
| + | [[Category: Guettler S]] | ||
| + | [[Category: Le Bihan Y-V]] | ||
| + | [[Category: Van Montfort RLM]] | ||
Current revision
Crystal structure of human TRF1 TRFH domain in complex with compound 10
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