1kd7
From Proteopedia
(New page: 200px<br /> <applet load="1kd7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kd7, resolution 2.80Å" /> '''Crystal structure o...) |
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caption="1kd7, resolution 2.80Å" /> | caption="1kd7, resolution 2.80Å" /> | ||
'''Crystal structure of an extracellular domain fragment of human BAFF'''<br /> | '''Crystal structure of an extracellular domain fragment of human BAFF'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KD7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1KD7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KD7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tnf]] | [[Category: tnf]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:12:42 2008'' |
Revision as of 14:12, 15 February 2008
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Crystal structure of an extracellular domain fragment of human BAFF
Overview
B cell activating factor (BAFF), a ligand belonging to the tumor necrosis, factor (TNF) family, plays a critical role in regulating survival and, activation of peripheral B cell populations and has been associated with, autoimmune disease. BAFF is known to interact with three receptors, BCMA, TACI and BAFF-R, that have distant similarities with other receptors of, the TNF family. We have determined the crystal structure of the, TNF-homologous domain of BAFF at 2.8 A resolution. The structure reveals, significant differences when compared to other TNF family members, including an unusually long D-E loop that participates in the formation of, a deep, concave and negatively charged region in the putative receptor, binding site. The BAFF structure was further used to generate a homology, model of APRIL, a closely related TNF family ligand that also binds to, BCMA and TACI, but not BAFF-R. Analysis of the putative receptor binding, sites of BAFF and APRIL suggests that differences in the D-E loop, structure and electrostatic surface potentials may be important for, determining binding specificities for BCMA, TACI and BAFF-R.
About this Structure
1KD7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes., Karpusas M, Cachero TG, Qian F, Boriack-Sjodin A, Mullen C, Strauch K, Hsu YM, Kalled SL, J Mol Biol. 2002 Feb 1;315(5):1145-54. PMID:11827482
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