1b7z

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{{STRUCTURE_1b7z| PDB=1b7z | SCENE= }}
{{STRUCTURE_1b7z| PDB=1b7z | SCENE= }}
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'''STRUCTURE OF OXALATE SUBSTITUTED DIFERRIC MARE LACTOFERRIN FROM COLOSTRUM'''
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===STRUCTURE OF OXALATE SUBSTITUTED DIFERRIC MARE LACTOFERRIN FROM COLOSTRUM===
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==Overview==
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Lactoferrin binds two Fe(3+) and two CO(2-)(3) ions with high affinity. It can also bind other metal ions and anions. In order to determine the perturbations in the environments of the binding sites in the N and C lobes and elsewhere in the protein, the crystal structure of oxalate-substituted diferric mare lactoferrin has been determined at 2.7 A resolution. The final model has a crystallographic R factor of 21.3% for all data in the resolution range 17.0-2.7 A. The substitution of an oxalate anion does not perturb the overall structure of the protein, but produces several significant changes at the metal-binding and anion-binding sites. The binding of the oxalate anion is symmetrical in both the N and C lobes, unlike in diferric dioxalate human lactoferrin, where the oxalate anion binds the metal ion symmetrically in the C lobe and asymmetrically in the N lobe.
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(as it appears on PubMed at http://www.pubmed.gov), where 10531474 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10531474}}
==About this Structure==
==About this Structure==
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[[Category: Lactoferrin]]
[[Category: Lactoferrin]]
[[Category: Metal binding site]]
[[Category: Metal binding site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:11:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:31:26 2008''

Revision as of 15:31, 30 June 2008

Image:1b7z.png

Template:STRUCTURE 1b7z

STRUCTURE OF OXALATE SUBSTITUTED DIFERRIC MARE LACTOFERRIN FROM COLOSTRUM

Template:ABSTRACT PUBMED 10531474

About this Structure

1B7Z is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

Structure of oxalate-substituted diferric mare lactoferrin at 2.7 A resolution., Sharma AK, Singh TP, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1792-8. PMID:10531474

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