1kd7

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{{STRUCTURE_1kd7| PDB=1kd7 | SCENE= }}
{{STRUCTURE_1kd7| PDB=1kd7 | SCENE= }}
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'''Crystal structure of an extracellular domain fragment of human BAFF'''
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===Crystal structure of an extracellular domain fragment of human BAFF===
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==Overview==
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B cell activating factor (BAFF), a ligand belonging to the tumor necrosis factor (TNF) family, plays a critical role in regulating survival and activation of peripheral B cell populations and has been associated with autoimmune disease. BAFF is known to interact with three receptors, BCMA, TACI and BAFF-R, that have distant similarities with other receptors of the TNF family. We have determined the crystal structure of the TNF-homologous domain of BAFF at 2.8 A resolution. The structure reveals significant differences when compared to other TNF family members, including an unusually long D-E loop that participates in the formation of a deep, concave and negatively charged region in the putative receptor binding site. The BAFF structure was further used to generate a homology model of APRIL, a closely related TNF family ligand that also binds to BCMA and TACI, but not BAFF-R. Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D-E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA, TACI and BAFF-R.
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(as it appears on PubMed at http://www.pubmed.gov), where 11827482 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11827482}}
==About this Structure==
==About this Structure==
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[[Category: Beta-sheet shandwich]]
[[Category: Beta-sheet shandwich]]
[[Category: Tnf]]
[[Category: Tnf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:35:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:09:41 2008''

Revision as of 07:09, 2 July 2008

Image:1kd7.png

Template:STRUCTURE 1kd7

Crystal structure of an extracellular domain fragment of human BAFF

Template:ABSTRACT PUBMED 11827482

About this Structure

1KD7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes., Karpusas M, Cachero TG, Qian F, Boriack-Sjodin A, Mullen C, Strauch K, Hsu YM, Kalled SL, J Mol Biol. 2002 Feb 1;315(5):1145-54. PMID:11827482

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