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|1h8b, 30 NMR models ()|
EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN
The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.
Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex., Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A, Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:11573089
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
- Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A. Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex. Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:11573089 doi:10.1038/nsb1001-853
- Atkinson RA, Joseph C, Dal Piaz F, Birolo L, Stier G, Pucci P, Pastore A. Binding of alpha-actinin to titin: implications for Z-disk assembly. Biochemistry. 2000 May 9;39(18):5255-64. PMID:10819994