1tbi

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.


1tbi ()
Resources: FirstGlance, PDBsum
Coordinates: save as pdb, mmCIF, xml


TERTIARY MODEL OF EXTRACELLULAR DOMAIN OF TYPE I RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA, THEORETICAL MODEL

Publication Abstract from PubMed

We have observed that the extracellular domain of T beta RI and protectin (CD59), an inhibitor of the membrane attack complex of complement, share structural features, a distinct spacing of ten cysteines and a C-terminal 'Cys-box'. Based on these common features and the recently determined NMR-structure of protectin, a three-dimensional model for the extracellular domain of T beta RI was constructed. After energy minimization and molecular dynamics simulation, a structure with four extending fingers (pes quattvordigitorum) and two clusters of charged residues was obtained. This model provides a view to the understanding of interactions between T beta RI, T beta RII and TGF beta during ligand recognition and signal transduction.

Extracellular domain of type I receptor for transforming growth factor-beta: molecular modelling using protectin (CD59) as a template., Jokiranta TS, Tissari J, Teleman O, Meri S, FEBS Lett. 1995 Nov 27;376(1-2):31-6. PMID:8521960

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Reference

  • Jokiranta TS, Tissari J, Teleman O, Meri S. Extracellular domain of type I receptor for transforming growth factor-beta: molecular modelling using protectin (CD59) as a template. FEBS Lett. 1995 Nov 27;376(1-2):31-6. PMID:8521960

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