1w7d

From Proteopedia

NMR Structure of Fasciclin-Like Protein From Rhodobacter sphaeroides

PDB ID 1w7d

Drag the structure with the mouse to rotate

Structural highlights

1w7d is a 1 chain structure with sequence from Cereibacter sphaeroides. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q3IXZ6_CERS4

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Fasciclin I (FAS1) domains have important roles in cell adhesion, which are not understood despite many structural and functional studies. Examples of FAS1 domain proteins include TGFBIp (betaig-h3) and periostin, which function in angiogenesis and development of cornea and bone, and are also highly expressed in cancer tissues. Here we report the structure of a single-domain bacterial fasciclin I protein, Fdp, in the free-living photosynthetic bacterium Rhodobacter sphaeroides, and show that it confers cell adhesion properties in vivo. A binding site is identified which includes the most highly conserved region and is adjacent to the N-terminus. By mapping this onto eukaryotic homologues, which all contain tandem FAS1 domains, it is concluded that the interaction site is normally buried in the dimer interface. This explains why corneal dystrophy mutations are concentrated in the C-terminal domain of TGFBIp and suggests new therapeutic approaches.

Structure and function of a bacterial Fasciclin I Domain Protein elucidates function of related cell adhesion proteins such as TGFBIp and periostin.,Moody RG, Williamson MP FEBS Open Bio. 2013 Jan 11;3:71-7. doi: 10.1016/j.fob.2013.01.001. Print 2013. PMID:23772377^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Moody RG, Williamson MP. Structure and function of a bacterial Fasciclin I Domain Protein elucidates function of related cell adhesion proteins such as TGFBIp and periostin. FEBS Open Bio. 2013 Jan 11;3:71-7. doi: 10.1016/j.fob.2013.01.001. Print 2013. PMID:23772377 doi:http://dx.doi.org/10.1016/j.fob.2013.01.001