2bug

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2bug, 19 NMR models ()
Non-Standard Residues:
Activity: Phosphoprotein phosphatase, with EC number 3.1.3.16
Related: 1a17, 1s95, 1wao
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

SOLUTION STRUCTURE OF THE TPR DOMAIN FROM PROTEIN PHOSPHATASE 5 IN COMPLEX WITH HSP90 DERIVED PEPTIDE

Publication Abstract from PubMed

Protein phosphatase 5 (Ppp5) is one of several proteins that bind to the Hsp90 chaperone via a tetratricopeptide repeat (TPR) domain. We report the solution structure of a complex of the TPR domain of Ppp5 with the C-terminal pentapeptide of Hsp90. This structure has the "two-carboxylate clamp" mechanism of peptide binding first seen in the Hop-TPR domain complexes with Hsp90 and Hsp70 peptides. However, NMR data reveal that the Ppp5 clamp is highly dynamic, and that there are multiple modes of peptide binding and mobility throughout the complex. Although this interaction is of very high affinity, relatively few persistent contacts are found between the peptide and the Ppp5-TPR domain, thus explaining its promiscuity in binding both Hsp70 and Hsp90 in vivo. We consider the possible implications of this dynamic structure for the mechanism of relief of autoinhibition in Ppp5 and for the mechanisms of TPR-mediated recognition of Hsp90 by other proteins.

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90., Cliff MJ, Harris R, Barford D, Ladbury JE, Williams MA, Structure. 2006 Mar;14(3):415-26. PMID:16531226

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2bug is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  • Cliff MJ, Harris R, Barford D, Ladbury JE, Williams MA. Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. Structure. 2006 Mar;14(3):415-26. PMID:16531226 doi:10.1016/j.str.2005.12.009

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