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2com
From Proteopedia
| 2com () | |||||||||
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| Gene: | LSD1 (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
The solution structure of the SWIRM domain of human LSD1
SWIRM is an evolutionarily conserved domain involved in several chromatin-modifying complexes. Recently, the LSD1 protein, which bears a SWIRM domain, was found to be a demethylase for Lys4-methylated histone H3. Here, we report a solution structure of the SWIRM domain of human LSD1. It forms a compact fold composed of 6 alpha helices, in which a 20 amino acid long helix (alpha4) is surrounded by 5 other short helices. The SWIRM domain structure could be divided into the N-terminal part (alpha1-alpha3) and the C-terminal part (alpha4-alpha6), which are connected to each other by a salt bridge. While the N-terminal part forms a SWIRM-specific structure, the C-terminal part adopts a helix-turn-helix (HTH)-related fold. We discuss a model in which the SWIRM domain acts as an anchor site for a histone tail.
Solution structure of the SWIRM domain of human histone demethylase LSD1., Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Watanabe S, Tomo Y, Hanada M, Ikari M, Sato M, Terada T, Nagase T, Ohara O, Shirouzu M, Tanaka A, Kigawa T, Yokoyama S, Structure. 2006 Mar;14(3):457-68. PMID:16531230
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2COM is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Watanabe S, Tomo Y, Hanada M, Ikari M, Sato M, Terada T, Nagase T, Ohara O, Shirouzu M, Tanaka A, Kigawa T, Yokoyama S. Solution structure of the SWIRM domain of human histone demethylase LSD1. Structure. 2006 Mar;14(3):457-68. PMID:16531230
Page seeded by OCA on Wed May 13 10:43:30 2009
Categories: Homo sapiens | Inoue, M. | Kigawa, T. | Koshiba, S. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Tanaka, A. | Tochio, N. | Umehara, T. | Yokoyama, S. | Aof2 | Histone modulation | Kiaa0601 | Lsd1 | National project on protein structural and functional analyse | Nppsfa | Oxidoreductase | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Swirm domain
