Structural highlights
Function
ISCU_ECOLI A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D-state is the preferred substrate for IscS. Converts to the S-state when an Fe-S cluster is assembled, which helps it dissociate from IscS to transfer the Fe-S to an acceptor. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.[1] [2]
References
- ↑ Urbina HD, Silberg JJ, Hoff KG, Vickery LE. Transfer of sulfur from IscS to IscU during Fe/S cluster assembly. J Biol Chem. 2001 Nov 30;276(48):44521-6. Epub 2001 Sep 27. PMID:11577100 doi:http://dx.doi.org/10.1074/jbc.M106907200
- ↑ Kim JH, Tonelli M, Markley JL. Disordered form of the scaffold protein IscU is the substrate for iron-sulfur cluster assembly on cysteine desulfurase. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):454-9. doi: 10.1073/pnas.1114372109., Epub 2011 Dec 27. PMID:22203963 doi:http://dx.doi.org/10.1073/pnas.1114372109