2lx1

Publication Abstract from PubMed

The RNA duplex, (5'GACGAGUGUCA)(2), has two conformations in equilibrium. The nuclear magnetic resonance solution structure reveals that the major conformation of the loop, 5'GAGU/3'UGAG, is novel and contains two unusual Watson-Crick/Hoogsteen GG pairs with G residues in the syn conformation, two A residues stacked on each other in the center of the helix with inverted sugars, and two bulged-out U residues. The structure provides a benchmark for testing approaches for predicting local RNA structure and a sequence that allows the design of a unique arrangement of functional groups and/or a conformational switch into nucleic acids.

Novel conformation of an RNA structural switch.,Kennedy SD, Kierzek R, Turner DH Biochemistry. 2012 Nov 20;51(46):9257-9. doi: 10.1021/bi301372t. Epub 2012 Nov, 12. PMID:23134175^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.