2mdp

Structural highlights

Function

GP12_BPT7 Plays a role in increasing the intracellular pool of dGTP. Interacts with and inhibits host dGTPase/dgt. The complex made of the host dGTPase and gene 1.2 protein creates a GTP-binding site of high affinity. Subsequent binding of GTP to the enzyme-inhibitor complex inhibits its dissociation.^{[1] [2]}

References

1. ↑ Nakai H, Richardson CC. The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein. J Biol Chem. 1990 Mar 15;265(8):4411-9. PMID:2155228
2. ↑ Myers JA, Beauchamp BB, Richardson CC. Gene 1.2 protein of bacteriophage T7. Effect on deoxyribonucleotide pools. J Biol Chem. 1987 Apr 15;262(11):5288-92. PMID:3549718