Structural highlights
Publication Abstract from PubMed
The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor.
Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P. Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor. J Med Chem. 2015 Nov 24. PMID:26599352 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b01285
