Structural highlights
Function
[KA191_MESMA] Selective inhibitor of high conductance calcium-activated potassium channels KCa1.1/KCNMA1. May be insect specific.[1] [PDB:3E8Y]
Publication Abstract from PubMed
Racemic protein crystallography, enabled by total chemical synthesis, has allowed us to determine the X-ray structure of native scorpion toxin BmBKTx1; direct methods were used for phase determination. This is the first example of a protein racemate that crystallized in space group I41/a.
X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.,Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA, Kent SB J Am Chem Soc. 2009 Feb 4;131(4):1362-3. PMID:19133782[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xu CQ, Brone B, Wicher D, Bozkurt O, Lu WY, Huys I, Han YH, Tytgat J, Van Kerkhove E, Chi CW. BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. J Biol Chem. 2004 Aug 13;279(33):34562-9. Epub 2004 Jun 3. PMID:15178692 doi:http://dx.doi.org/10.1074/jbc.M312798200
- ↑ Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA, Kent SB. X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. J Am Chem Soc. 2009 Feb 4;131(4):1362-3. PMID:19133782 doi:10.1021/ja8077973
