Structural highlights
Publication Abstract from PubMed
The bacterial flagellum is assembled by a multicomponent transport apparatus categorized as a Type III secretion (T3S) system. The secretion of proteins that assemble into the flagellum is driven by the proton motive force. The periplasmic protein FlhE is a member of the flhBAE operon in the majority of bacteria where FlhE is found. FlhA and FlhB are established components of the flagellar T3S system. The absence of FlhE results in a proton leak through the flagellar system, inappropriate secretion patterns, and cell death, indicating that FlhE regulates an important aspect of proper flagellar biosynthesis. We isolated FlhE from the periplasm of Salmonella and solved its structure to 1.5A resolution. Possible roles of FlhE, including that of a chaperone, are discussed.
Structure of Salmonella FlhE, conserved member of a flagellar Type III secretion operon.,Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM J Mol Biol. 2014 Dec 26. pii: S0022-2836(14)00647-0. doi:, 10.1016/j.jmb.2014.11.022. PMID:25545591[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM. Structure of Salmonella FlhE, conserved member of a flagellar Type III secretion operon. J Mol Biol. 2014 Dec 26. pii: S0022-2836(14)00647-0. doi:, 10.1016/j.jmb.2014.11.022. PMID:25545591 doi:http://dx.doi.org/10.1016/j.jmb.2014.11.022
