Bacterial thiolase

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3D structure (1DM3) of the bacterial Zoogloea ramigera biosynthetic thiolase

Additional Resources

For additional information, see: Metabolic Disorders

3D structures of Thiolase

Thiolase


References

  1. Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Janis J, Wierenga RK. The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry. Biochem J. 2018 Dec 20. pii: BCJ20180788. doi: 10.1042/BCJ20180788. PMID:30573650 doi:http://dx.doi.org/10.1042/BCJ20180788
  2. Williams SF, Palmer MA, Peoples OP, Walsh CT, Sinskey AJ, Masamune S. Biosynthetic thiolase from Zoogloea ramigera. Mutagenesis of the putative active-site base Cys-378 to Ser-378 changes the partitioning of the acetyl S-enzyme intermediate. J Biol Chem. 1992 Aug 15;267(23):16041-3. PMID:1353760
  3. 3.0 3.1 Kursula P, Ojala J, Lambeir AM, Wierenga RK. The catalytic cycle of biosynthetic thiolase: a conformational journey of an acetyl group through four binding modes and two oxyanion holes. Biochemistry. 2002 Dec 31;41(52):15543-56. PMID:12501183
  4. 4.0 4.1 4.2 Merilainen G, Poikela VM, Kursula P, Wierenga RK. The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensation. Biochemistry. 2009 Oct 20. PMID:19842716 doi:10.1021/bi901069h
  5. 5.0 5.1 Fukao T, Nguyen HT, Nguyen NT, Vu DC, Can NT, Pham AT, Nguyen KN, Kobayashi H, Hasegawa Y, Bui TP, Niezen-Koning KE, Wanders RJ, de Koning T, Nguyen LT, Yamaguchi S, Kondo N. A common mutation, R208X, identified in Vietnamese patients with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Mol Genet Metab. 2010 May;100(1):37-41. Epub 2010 Jan 21. PMID:20156697 doi:10.1016/j.ymgme.2010.01.007
  6. Modis Y, Wierenga RK. Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase. J Mol Biol. 2000 Apr 14;297(5):1171-82. PMID:10764581 doi:10.1006/jmbi.2000.3638
  7. Haapalainen AM, Merilainen G, Wierenga RK. The thiolase superfamily: condensing enzymes with diverse reaction specificities. Trends Biochem Sci. 2006 Jan;31(1):64-71. Epub 2005 Dec 13. PMID:16356722 doi:10.1016/j.tibs.2005.11.011
  8. Jiang C, Kim SY, Suh DY. Divergent evolution of the thiolase superfamily and chalcone synthase family. Mol Phylogenet Evol. 2008 Dec;49(3):691-701. Epub 2008 Sep 12. PMID:18824113 doi:10.1016/j.ympev.2008.09.002
  9. Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Janis J, Wierenga RK. The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry. Biochem J. 2018 Dec 20. pii: BCJ20180788. doi: 10.1042/BCJ20180788. PMID:30573650 doi:http://dx.doi.org/10.1042/BCJ20180788
  10. 10.0 10.1 Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK. Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis. Tuberculosis (Edinb). 2014 Jul;94(4):405-12. doi: 10.1016/j.tube.2014.03.003., Epub 2014 Apr 4. PMID:24825023 doi:http://dx.doi.org/10.1016/j.tube.2014.03.003

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