Biotin Protein Ligase

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Biotin protein ligase complex with biotinyl-5-AMP and sulfate (PDB code 4op0)

3D structures of Biotin Protein Ligase

Updated on 05-March-2018


  1. Pendini NR, Bailey LM, Booker GW, Wilce MC, Wallace JC, Polyak SW. Microbial biotin protein ligases aid in understanding holocarboxylase synthetase deficiency. Biochim Biophys Acta. 2008 Jul-Aug;1784(7-8):973-82. Epub 2008 Apr 9. PMID:18442489 doi:10.1016/j.bbapap.2008.03.011
  2. Wang J, Beckett D. A conserved regulatory mechanism in bifunctional biotin protein ligases. Protein Sci. 2017 Aug;26(8):1564-1573. doi: 10.1002/pro.3182. Epub 2017 May 11. PMID:28466579 doi:
  3. Bagautdinov B, Kuroishi C, Sugahara M, Kunishima N. Purification, crystallization and preliminary crystallographic analysis of the biotin-protein ligase from Pyrococcus horikoshii OT3. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt, 2):193-5. Epub 2005 Jan 8. PMID:16510991 doi:10.1107/S1744309104034360
  4. Wilson KP, Shewchuk LM, Brennan RG, Otsuka AJ, Matthews BW. Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9257-61. PMID:1409631

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