Function
Chaperone protein ClpB (ClpB) reactivates aggregated proteins in cooperation with Hsp70[1]. ClpB is an ATP-dependent chaperone which can rescue proteins from an aggregated state.
Disease
CLPb deficiency is a rare disorder characterized by neurological problems and shortage of white blood cells[2]. ClpB mutations cause progressive brain atrophy[3].
Structural highlights
The 3D structure of ClpB trimeric complex with the nucleotide AMPPNP shows the chaperone to be comprised of several domains: , first nucleotide-binding domain , a long coiled-coil domain, a and a . The at NBD1 includes several hydrophobic residues as does the [4]. The long coiled-coil segments are implicated in the desaggregase activity of ClpB via their ability to move in opposite directions between subunits generating the mechanical force needed.
ClpB 3D structures
3D structures of ClpB