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Bovine γ-chymotrypsin A (residues 1-13 in pink, 16-146 in cyan, 149-245 in gold) complex with inhibitor (PDB code 7gch)

3D Structures of Chymotrypsin

Updated on 04-February-2019

The Chy precursor is the inactive chymotrypsinogen (Chygen) which gets cleaved 3 times by trypsin and chymotrypsin losing a 4 amino acid long peptide to become the active Chy. γ-Chy is a covalent acyl adduct of α-Chy. δ-Chy results when Chygen is cleaved only twice.


  1. Appel W. Chymotrypsin: molecular and catalytic properties. Clin Biochem. 1986 Dec;19(6):317-22. PMID:3555886

Further reading

You can learn more about chymotrypsin structure, function and regulation in this publicly available chapter of the Biochemistry textbook by Berg, Tymoczka and Stryer.

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