Ecotin

From Proteopedia

The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) 1id5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Ecotin (ECO) is a serine protease inhibitor found in the periplasm of E. coli. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.[1] with . in thrombin heavy chain (1id5).[2] Water molecules shown as red spheres.

3D Structures of Ecotin

Updated on 08-February-2023

References

1. ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:http://dx.doi.org/10.1042/BJ20031790
2. ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582