Glutathione Reductase

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Glutathione reductase, also known as GSH reductase, is found in the human cells and converts oxidized glutathione (GSSG) to two molecules of reduced gluthatione (GSH) [1]. EC:1.8.1.7. For more details see Molecular Playground/Glutathione Reductase.

Glutathione reductase dimer complex with FAD and chloride ion, 3o0h

3D structures of glutathione reductase

Updated on 26-December-2019

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Berkholz DS, Faber HR, Savvides SN, Karplus PA. Catalytic cycle of human glutathione reductase near 1 A resolution. J Mol Biol. 2008 Oct 3;382(2):371-84. Epub 2008 Jul 7. PMID:18638483 doi:10.1016/j.jmb.2008.06.083
  2. Holleschau AM, Rathbun WB. Thermal inactivation study of glutathione peroxidase and glutathione reductase activities in lenses of primates and non-primates. Curr Eye Res. 1991 Mar;10(3):221-9. PMID:2044390
  3. 3.0 3.1 Kelner MJ, Montoya MA. Structural organization of the human glutathione reductase gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence. Biochem Biophys Res Commun. 2000 Mar 16;269(2):366-8. PMID:10708558 doi:10.1006/bbrc.2000.2267
  4. 4.0 4.1 Dym O, Eisenberg D. Sequence-structure analysis of FAD-containing proteins. Protein Sci. 2001 Sep;10(9):1712-28. PMID:11514662 doi:10.1110/ps.12801
  5. 5.0 5.1 Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem. 2005 Oct;16(10):577-86. PMID:16111877 doi:10.1016/j.jnutbio.2005.05.013
  6. Pastore A, Federici G, Bertini E, Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta. 2003 Jul 1;333(1):19-39. PMID:12809732
  7. Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem. 2005 Oct;16(10):577-86. PMID:16111877 doi:10.1016/j.jnutbio.2005.05.013
  8. Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA. Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2680-5. PMID:10716996
  9. 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 Kamerbeek NM, van Zwieten R, de Boer M, Morren G, Vuil H, Bannink N, Lincke C, Dolman KM, Becker K, Schirmer RH, Gromer S, Roos D. Molecular basis of glutathione reductase deficiency in human blood cells. Blood. 2007 Apr 15;109(8):3560-6. Epub 2006 Dec 21. PMID:17185460 doi:10.1182/blood-2006-08-042531

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