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Gramicidin Channel in Lipid Bilayer

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Theoretical Model: The structure described on this page was determined theoretically, and hence should be interpreted with caution.

Theoretical model of gramicidin in a lipid bilayer (phosphatidyl ethanolamine).

Two copies of the gramicidin protein are shown here () arranged as they are believed to be when they form a channel through a lipid bilayer membrane[1]. The shape of the protein is shown transparent (ghostly), and a backbone trace connecting the alpha carbon atoms of each amino acid chain is opaque (solid).

  • Show of the gramicidin protein chains.
  • (Most hydrogen atoms are omitted.)
  • Show . Notice how the hydrophobic lipid "tails" exclude water.
  • Water passes .
  • Show .

  • Show only . For an explanation of their structure, see the detailed tutorial, also disponible en español.

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See Also

Notes

References

  1. Crouzy S, Woolf TB, Roux B. A molecular dynamics study of gating in dioxolane-linked gramicidin A channels. Biophys J. 1994 Oct;67(4):1370-86. PMID:7529578 doi:http://dx.doi.org/10.1016/S0006-3495(94)80618-6

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