Heme oxygenase

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Rat heme oxygenase complex with imidazole derivative and Cl- ion (green) (PDB entry 2dy5)


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Sugishima M, Higashimoto Y, Oishi T, Takahashi H, Sakamoto H, Noguchi M, Fukuyama K. X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase. Biochemistry. 2007 Feb 20;46(7):1860-7. Epub 2007 Jan 25. PMID:17253780 doi:10.1021/bi062264p
  2. 2.0 2.1 Lad L, Ortiz de Montellano PR, Poulos TL. Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage. J Inorg Biochem. 2004 Nov;98(11):1686-95. PMID:15522396 doi:10.1016/j.jinorgbio.2004.07.004
  3. Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003 Aug;24(8):449-55. PMID:12909459
  4. 4.0 4.1 Caughey WS, Smythe GA, O'Keeffe DH, Maskasky JE, Smith MI. Heme A of cytochrome c oxicase. Structure and properties: comparisons with hemes B, C, and S and derivatives. J Biol Chem. 1975 Oct 10;250(19):7602-22. PMID:170266
  5. Bonkovsky HL, Healey JF, Pohl J. Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes. Eur J Biochem. 1990 Apr 20;189(1):155-66. PMID:2158889
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Rahman MN, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z. X-ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(Adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: A Common Binding Mode for Imidazole-Based Heme Oxygenase-1 Inhibitors. J Med Chem. 2008 Sep 18. PMID:18798608 doi:10.1021/jm800505m
  7. 7.0 7.1 Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 1988 Jul;2(10):2557-68. PMID:3290025
  8. 8.0 8.1 Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med. 2002 Mar;8(3):240-6. PMID:11875494 doi:10.1038/nm0302-240
  9. Evans JP, Niemevz F, Buldain G, de Montellano PO. Isoporphyrin intermediate in heme oxygenase catalysis. Oxidation of alpha-meso-phenylheme. J Biol Chem. 2008 Jul 11;283(28):19530-9. Epub 2008 May 16. PMID:18487208 doi:10.1074/jbc.M709685200
  10. 10.0 10.1 Raval CM, Lee PJ. Heme oxygenase-1 in lung disease. Curr Drug Targets. 2010 Dec;11(12):1532-40. PMID:20704548

This page originally authored by Barinder Chahal

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