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Molecular Playground/ERMan1

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ERMan1

Alpha-mannosidases I(ERMan1) is a human protein that resides in the endoplasmic reticulum(ER). ERMan1 is a member of the class 1 glycosylhydrolase family 47 group proteins and sports a Tim-barrel fold. Asparagine(N)-linked glycans are common covalent modifiers in the ER that aid in protein folding and trafficking. ERMan1 trims N-linked glycans to target a misfolded protein for degradation. The slow acting kinetics of ERMan1 have been proposed to act as a timer for protein degradation, creating a discrete window for protein folding followed by degradation if the substrate protein cannot reach the native state.




Human α-mannosidase class I complex with mannopyranoside, sulfate, 1,4-butanediol, Ca+2 ion, 1x9d
Ligands: , , ,
Gene: MAN1B1 (Homo sapiens)
Activity: Mannosyl-oligosaccharide 1,2-alpha-mannosidase, with EC number 3.2.1.113
Related: 1fmi
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



"Molecular Playground banner: A catalytic timer for protein degradation."

3D structures of mannosidases

Mannosidase

[1] [2]

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Johan Sunryd, Michal Harel

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