Molecular playground/beta 2 microglobulin

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Human beta-2 microglobulin, 2f8o
Gene: B2M (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml

Banner: Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex, and in dialysis patients, it forms amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA).

DRA is a complication of dialysis treatment in which these fibrils build up in joints causing pain and often eventually necessitating joint replacement. beta-2-microglobulin can self-assemble into amyloid fibrils under physiological conditions in vitro when copper is present.

Fibril assembly begins with the formation of a . Dimer formation is initiated when copper binds near the , copper binding causes structural changes throughout the protein, creating two new . These planes interact in an antiparallel fashion forming the dimer.

3D structures of β-2 microglobulin

Beta-2 microglobulin

Additional Resources

For additional information, see: Metabolic Disorders

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Nick Borotto, David Canner, Michal Harel

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