NADPH-Cytochrome P450 Reductase

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Human NADPH-Cytochrome P450 reductase FMN-binding and FAD/NADPH domains complex with FMN, FAD, NADP and Ca+2 ion (green) (PDB entry 3qe2)

3D Structures of NADPH-Cytochrome P450 Reductase

Updated on 06-November-2019


  1. Hamdane D, Xia C, Im SC, Zhang H, Kim JJ, Waskell L. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26. PMID:19171935 doi:10.1074/jbc.M807868200
  2. Pandey AV, Fluck CE. NADPH P450 oxidoreductase: structure, function, and pathology of diseases. Pharmacol Ther. 2013 May;138(2):229-54. doi: 10.1016/j.pharmthera.2013.01.010., Epub 2013 Jan 24. PMID:23353702 doi:
  3. Xia C, Panda SP, Marohnic CC, Martasek P, Masters BS, Kim JJ. Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13486-91. Epub 2011 Aug 1. PMID:21808038 doi:10.1073/pnas.1106632108

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