Phenylpyruvate decarboxylase

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Phenylpyruvate decarboxylase dimer complex with phenylpyruvate, deaza-ThDP and Mg+2 (green) ion 2q5o

3D Structures of phenylpyruvate decarboxylase

2q5j, 2q5l – AbPPDC + deaza-ThDP derivative – Azospirillum brasilense

2q5o - AbPPDC + deaza-ThDP + phenylpyruvate

2q5q - AbPPDC + deaza-ThDP + phenylvalerate

References

  1. Vuralhan Z, Morais MA, Tai SL, Piper MD, Pronk JT. Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae. Appl Environ Microbiol. 2003 Aug;69(8):4534-41. PMID:12902239
  2. Versees W, Spaepen S, Wood MD, Leeper FJ, Vanderleyden J, Steyaert J. Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase. J Biol Chem. 2007 Nov 30;282(48):35269-78. Epub 2007 Sep 28. PMID:17905741 doi:http://dx.doi.org/10.1074/jbc.M706048200

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