Prolactin

From Proteopedia

Function Prolactin (PRL) is a hormone which has numerous effects. It enables females to produce milk. PRL provides the body with sexual gratification. PRL promotes neurogenesis in maternal and fetal brains. PRL stimulates cells which are responsible for the formation of myelin coating on axons[1]. See also Prolactin (Hebrew). Disease PRL has immunomodulatory effect and plays a role in lupus and rheumatoid arthritis[2]

spinqualitylabelsall models Human prolactin (grey) complex with prolactin receptor extracellular domain (green), Na+ (purple) and Ca+2 (green) ions (PDB code 3mzg). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of prolactin

Updated on 07-October-2020

1rw5 – hPRL – human - NMR
2q98 – hPRL (mutant)
3mzg, 3npz – hPRL + hPRL receptor extracellular domain
3d48, 3n06, 3n0p, 3ncb – hPRL (mutant) + hPRL receptor extracellular domain
3ncc, 3nce, 3ncf – hPRL (mutant) + hPRL receptor extracellular domain (mutant)
3ew3 – hPRL + rPRL receptor extracellular domain - rat

References

1. ↑ Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev. 2000 Oct;80(4):1523-631. PMID:11015620
2. ↑ Chuang E, Molitch ME. Prolactin and autoimmune diseases in humans. Acta Biomed. 2007;78 Suppl 1:255-61. PMID:17465339