Prostaglandin E synthase
From Proteopedia
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3D Structures of prostaglandin E synthase
Updated on 13-September-2023
3dww, 4al0, 4wab, 4bpm – hPGES-1 + glutathione – human
4al1 – hPGES-1 + glutathione analog
6vl4 – hPGES-1 + inhibitor
5bqg, 5bqh, 5bqi, 5k0i, 5t36, 5t37, 5tl9, 4yk5, 4yl0, 4yl1, 4yl3 – hPGES-1 + glutathione + inhibitor
7l7j – hPGES-3 + Hsp90 – Cryo EM
7l7i – hPGES-3 + Hsp90 + FKBP5 – Cryo EM
7krj – hPGES-3 + Hsp90 + glucocorticoid receptor – Cryo EM
1z9h – MaPGES-2 + indomethacin – Macaque
2pbj – MaPGES-2 + heme + glutathione
7y04 – mPGES-3 + Hsp90 + AHR - mouse – Cryo EM
8h77 – mPGES-3 + Hsp90 + AHR + AHR-interacting protein – Cryo EM
References
- ↑ Murakami M, Nakatani Y, Tanioka T, Kudo I. Prostaglandin E synthase. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:383-99. PMID:12432931
- ↑ Kudo I, Murakami M. Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis. J Biochem Mol Biol. 2005 Nov 30;38(6):633-8. PMID:16336776
- ↑ Murakami M, Kudo I. Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr Pharm Des. 2006;12(8):943-54. PMID:16533161
- ↑ Luz JG, Antonysamy S, Kuklish SL, Condon B, Lee MR, Allison D, Yu XP, Chandrasekhar S, Backer R, Zhang A, Russell M, Chang SS, Harvey A, Sloan AV, Fisher MJ. Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. J Med Chem. 2015 May 20. PMID:25961169 doi:http://dx.doi.org/10.1021/acs.jmedchem.5b00330
