Rac

From Proteopedia

Contents 1 Function 2 Disease 3 Structural highlights 4 3D structures of Rac Function The small G-protein Rac or Ras-related C3 botulinum toxin substrate. Rac1 is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes[1]. Rac2 is expressed in hematopoietic cells exclusively[2]. Rac3 binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. Disease Mutations in Rac2 are associated with neutrophil immunodeficiency syndrome. Structural highlights The interactions between Rac1 and YpkA are via switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA[3]. GDP binding site on Rac1. 3D structures of Rac Rac 3D structures

spinqualitylabelsall models Human Rac1 (magenta) complex with YpkA (cyan), GDP and Mg+2 ion (green) (PDB code 2h7v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013, Feb 15. PMID:23412604 doi:http://dx.doi.org/10.1007/s00125-013-2849-5
2. ↑ Lougaris V, Baronio M, Gazzurelli L, Benvenuto A, Plebani A. RAC2 and primary human immune deficiencies. J Leukoc Biol. 2020 Aug;108(2):687-696. PMID:32542921 doi:10.1002/JLB.5MR0520-194RR
3. ↑ Prehna G, Ivanov MI, Bliska JB, Stebbins CE. Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors. Cell. 2006 Sep 8;126(5):869-80. PMID:16959567 doi:10.1016/j.cell.2006.06.056