SARS Coronavirus Main Proteinase

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Human SARS coronavirus proteinase dimer complex with benzoic acid, dimethylamino benzoic acid and DMSO, 2vj1

3D structures of virus proteinase

Updated on 17-September-2018

References

  1. Takahashi D, Hiromasa Y, Kim Y, Anbanandam A, Yao X, Chang KO, Prakash O. Structural and dynamics characterization of norovirus protease. Protein Sci. 2013 Jan 15. doi: 10.1002/pro.2215. PMID:23319456 doi:http://dx.doi.org/10.1002/pro.2215
  2. Murray, Patrick R., Ken S. Rosenthal, and Michael A. Pfaller. "Coronaviruses and Noroviruses." Medical Microbiology. 6th ed. Philadelphia: Mosby/Elsevier, 2009. 565-68. Print.
  3. Ziebuhr, J., Herold,J., and Siddell, S.G. (1995). Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity. J. Virol. 69, 4331-4338.
  4. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003;348:1953-1966
  5. "Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003". WHO. Retrieved 2008-10-31.
  6. Li W, Shi Z, Yu M, et al. (2005). "Bats are natural reservoirs of SARS-like coronaviruses". Science (journal) 310 (5748): 676–9. doi:10.1126/science.1118391. PMID 16195424.
  7. Ziebuhr, J., Snijder, E.J., and Gorbaleya, A.E. (2000). Virus-encoded proteinases and proteolytic processing in Nidovirales. J. Gen. Virol. 81, 853-879.
  8. Anad, K., Ziebhr, J., Wadhani, P., Mesters, J.R., and Hilgenfeld, R. (2003). Coronavirus main protease (3CLPro) structure: basis for design of anti-SARS drugs. Science300, 1763-1767.
  9. Anad, K., Ziebhr, J., Wadhani, P., Mesters, J.R., and Hilgenfeld, R. (2003). Coronavirus main protease (3CLPro) structure: basis for design of anti-SARS drugs. Science300, 1763-1767.
  10. Verschueren, Koen H.G., Ksenia Pumpor, Stefan Anemüller, Shuai Chen, Jeroen R. Mesters, and Rolf Hilgenfeld. "A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters." Chemistry & Biology 15.6 (2008): 597-606. Web. Oct. 2010.

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