STAS domain of the SLC26 anion transporter prestin

From Proteopedia

Jump to: navigation, search

The SulP family

The Sulphate permease SulP is a large and diverse family of integral membrane proteins, with members found in eubacteria, plants, fungi and mammals (SLC26). These anion transporters show a similar structural organization: a highly conserved transmembrane central core and a less conserved cytoplasmic C-terminal portion, comprising a STAS domain.

The STAS domain

The STAS domain (Sulphate Transporter and Anti-Sigma factor antagonist) was identified by omology between the SulP gene family and the bacterial anti-sigma factor antagonist (ASA) SpoIIAA of Bacillus subtilis. The STAS domain is involved in the function/regulation of SulP transporters. Most probably the 3D structures of the anion transporters STAS domains significantly deviate from those of the bacterial ASAs, whose structures are known.

Proteopedia Page Contributors and Editors (what is this?)

Elisa Pasqualetto

Personal tools