Sulfurtransferase

From Proteopedia

Human mercaptopyruvate sulfurtransferase with mercaptocysteine complex with pyruvate, sulfate (PDB entry 4jgt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Sulfurtransferase (ST) are enzymes which transfer sulfur-containing groups[1]. Thiosulfate ST (TST) catalyzes the conversion of thiosulfate and cyanide to sulfite and thiocyanate[2]. Mercaptopyruvate ST (MST) transfers sulfate from mercaptopyruvate[3]. Relevance Inhibitors of MST suppress H2S production and this make non sulfur bacteria like E. coli and Bacillus anthracis sensitive to antibiotics[4]. Structural highlights The [5]. Water molecules are shown as red spheres.

3D Structures of sulfurtransferase

Updated on 01-March-2024

References

1. ↑ Papenbrock J, Guretzki S, Henne M. Latest news about the sulfurtransferase protein family of higher plants. Amino Acids. 2011 Jun;41(1):43-57. doi: 10.1007/s00726-010-0478-6. Epub 2010 Feb , 5. PMID:20135153 doi:http://dx.doi.org/10.1007/s00726-010-0478-6
2. ↑ Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipila P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. PMID:27270587 doi:http://dx.doi.org/10.1038/nm.4115
3. ↑ Nakamura T, Yamaguchi Y, Sano H. Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities. Eur J Biochem. 2000 Sep;267(17):5621-30. PMID:10951223
4. ↑ Shatalin K, Shatalina E, Mironov A, Nudler E. H2S: a universal defense against antibiotics in bacteria. Science. 2011 Nov 18;334(6058):986-90. doi: 10.1126/science.1209855. PMID:22096201 doi:http://dx.doi.org/10.1126/science.1209855
5. ↑ Yadav PK, Yamada K, Chiku T, Koutmos M, Banerjee R. Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase. J Biol Chem. 2013 May 22. PMID:23698001 doi:10.1074/jbc.M113.466177