Trypsin

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Bovine trypsin complex with benzamidine derivative and Ca+2 ion (green) (PDB code 1y3v)

3D structures of Trypsin

Updated on 27-September-2018

References

  1. Trypsin. 2010. 30 October 2010 <http://www.worthington-biochem.com/tyr/default.html>
  2. Trypsin. 30 October 2010 <http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzyme/trypsin.html>.
  3. Image From: http://chemistry.umeche.maine.edu/MAT500/Peptidase1.html
  4. Trypsin. 2010. 30 October 2010 <http://www.worthington-biochem.com/tyr/default.html>
  5. Pratt, C.W., Voet, D., Voet, J.G. Fundamentals of Biochemistry - Life at the Molecular Level - Third Edition. Voet, Voet and Pratt, 2008.
  6. Structural Biochemistry. 10 June 2010. 30 October 2010.<http://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme/Catalytic_Triad>.
  7. Image From: 503-3a-2serineprotease.jpg
  8. Williams, Loren. Georgia Tech. http://www2.chemistry.gatech.edu/~1W26/bcourse_information/6521/protein/serine_protease/triad_1/html.
  9. Structural Biochemistry. 10 June 2010. 30 October 2010.<http://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme/Catalytic_Triad>.
  10. Pratt, C.W., Voet, D., Voet, J.G. Fundamentals of Biochemistry - Life at the Molecular Level - Third Edition. Voet, Voet and Pratt, 2008.
  11. Joshi RS, Mishra M, Tamhane VA, Ghosh A, Sonavane U, Suresh CG, Joshi R, Gupta VS, Giri AP. The remarkable efficiency of a Pin-II proteinase inhibitor sans two conserved disulfide bonds is due to enhanced flexibility and hydrogen bond density in the reactive site loop. J Biomol Struct Dyn. 2012 Dec 20. PMID:23256852 doi:10.1080/07391102.2012.745378
  12. 12.0 12.1 Green TR, Ryan CA. Wound-Induced Proteinase Inhibitor in Plant Leaves: A Possible Defense Mechanism against Insects. Science. 1972 Feb 18;175(4023):776-7. PMID:17836138 doi:10.1126/science.175.4023.776
  13. Kong L, Ranganathan S. Tandem duplication, circular permutation, molecular adaptation: how Solanaceae resist pests via inhibitors. BMC Bioinformatics. 2008;9 Suppl 1:S22. PMID:18315854 doi:10.1186/1471-2105-9-S1-S22
  14. Johnson R, Narvaez J, An G, Ryan C. Expression of proteinase inhibitors I and II in transgenic tobacco plants: effects on natural defense against Manduca sexta larvae. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9871-5. PMID:2602379
  15. Duan X, Li X, Xue Q, Abo-el-Saad M, Xu D, Wu R. Transgenic rice plants harboring an introduced potato proteinase inhibitor II gene are insect resistant. Nat Biotechnol. 1996 Apr;14(4):494-8. PMID:9630927 doi:10.1038/nbt0496-494
  16. Nielsen KJ, Heath RL, Anderson MA, Craik DJ. Structures of a series of 6-kDa trypsin inhibitors isolated from the stigma of Nicotiana alata. Biochemistry. 1995 Nov 7;34(44):14304-11. PMID:7578034
  17. Scanlon MJ, Lee MC, Anderson MA, Craik DJ. Structure of a putative ancestral protein encoded by a single sequence repeat from a multidomain proteinase inhibitor gene from Nicotiana alata. Structure. 1999 Jul 15;7(7):793-802. PMID:10425681
  18. Lee MC, Scanlon MJ, Craik DJ, Anderson MA. A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein. Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353 doi:10.1038/9293
  19. Schirra HJ, Scanlon MJ, Lee MC, Anderson MA, Craik DJ. The solution structure of C1-T1, a two-domain proteinase inhibitor derived from a circular precursor protein from Nicotiana alata. J Mol Biol. 2001 Feb 9;306(1):69-79. PMID:11178894 doi:10.1006/jmbi.2000.4318
  20. Schirra HJ, Craik DJ. Structure and folding of potato type II proteinase inhibitors: circular permutation and intramolecular domain swapping. Protein Pept Lett. 2005 Jul;12(5):421-31. PMID:16029154
  21. Schirra HJ, Anderson MA, Craik DJ. Structural refinement of insecticidal plant proteinase inhibitors from Nicotiana alata. Protein Pept Lett. 2008;15(9):903-9. PMID:18991765
  22. Schirra HJ, Guarino RF, Anderson MA, Craik DJ. Selective removal of individual disulfide bonds within a potato type II serine proteinase inhibitor from Nicotiana alata reveals differential stabilization of the reactive-site loop. J Mol Biol. 2010 Jan 22;395(3):609-26. Epub 2009 Nov 17. PMID:19925809 doi:10.1016/j.jmb.2009.11.031
  23. Li XQ, Zhang T, Donnelly D. Selective loss of cysteine residues and disulphide bonds in a potato proteinase inhibitor II family. PLoS One. 2011 Apr 11;6(4):e18615. PMID:21494600 doi:10.1371/journal.pone.0018615
  24. Barrette-Ng IH, Ng KK, Cherney MM, Pearce G, Ryan CA, James MN. Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg. J Biol Chem. 2003 Jun 27;278(26):24062-71. Epub 2003 Apr 8. PMID:12684499 doi:10.1074/jbc.M302020200
  25. Dunse KM, Kaas Q, Guarino RF, Barton PA, Craik DJ, Anderson MA. Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15016-21. Epub 2010 Aug 9. PMID:20696921 doi:10.1073/pnas.1009327107
  26. Tamhane VA, Giri AP, Kumar P, Gupta VS. Spatial and temporal expression patterns of diverse Pin-II proteinase inhibitor genes in Capsicum annuum Linn. Gene. 2009 Aug 1;442(1-2):88-98. Epub 2009 Apr 22. PMID:19393726 doi:10.1016/j.gene.2009.04.012
  27. Tamhane VA, Chougule NP, Giri AP, Dixit AR, Sainani MN, Gupta VS. In vivo and in vitro effect of Capsicum annum proteinase inhibitors on Helicoverpa armigera gut proteinases. Biochim Biophys Acta. 2005 Mar 11;1722(2):156-67. Epub 2005 Jan 12. PMID:15715970 doi:10.1016/j.bbagen.2004.12.017

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