User:Rafael Romero Becerra/Sandbox 1

From Proteopedia

Jump to: navigation, search

PCSK9: Pro-protein convertase subtilisin/kexin type 9

Caption for this structure

References

  1. Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33. Epub 2003 Jan 27. PMID:12552133 doi:http://dx.doi.org/10.1073/pnas.0335507100
  2. Abifadel M, Rabes JP, Devillers M, Munnich A, Erlich D, Junien C, Varret M, Boileau C. Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease. Hum Mutat. 2009 Apr;30(4):520-9. doi: 10.1002/humu.20882. PMID:19191301 doi:http://dx.doi.org/10.1002/humu.20882
  3. Hess CN, Low Wang CC, Hiatt WR. PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes. Annu Rev Med. 2017 Nov 2. doi: 10.1146/annurev-med-042716-091351. PMID:29095667 doi:http://dx.doi.org/10.1146/annurev-med-042716-091351
  4. Piper DE, Jackson S, Liu Q, Romanow WG, Shetterly S, Thibault ST, Shan B, Walker NP. The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol. Structure. 2007 May;15(5):545-52. PMID:17502100 doi:http://dx.doi.org/10.1016/j.str.2007.04.004
  5. Unknown PubmedID 10.1016/j.abb.2003.09.011
  6. Abifadel M, Rabes JP, Devillers M, Munnich A, Erlich D, Junien C, Varret M, Boileau C. Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease. Hum Mutat. 2009 Apr;30(4):520-9. doi: 10.1002/humu.20882. PMID:19191301 doi:http://dx.doi.org/10.1002/humu.20882
  7. Hess CN, Low Wang CC, Hiatt WR. PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes. Annu Rev Med. 2017 Nov 2. doi: 10.1146/annurev-med-042716-091351. PMID:29095667 doi:http://dx.doi.org/10.1146/annurev-med-042716-091351
  8. Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. J Biol Chem. 2006 Oct 13;281(41):30561-72. Epub 2006 Aug 15. PMID:16912035 doi:http://dx.doi.org/10.1074/jbc.M606495200
  9. Dewpura T, Raymond A, Hamelin J, Seidah NG, Mbikay M, Chretien M, Mayne J. PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. FEBS J. 2008 Jul;275(13):3480-93. doi: 10.1111/j.1742-4658.2008.06495.x. Epub, 2008 May 22. PMID:18498363 doi:http://dx.doi.org/10.1111/j.1742-4658.2008.06495.x
  10. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  11. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Rafael Romero Becerra

Personal tools